Physiological Simulation
Noise-stable integration for cardiac and neural tissue models
Standard implicit solvers depend on converged Jacobian estimates. When the right-hand side includes stochastic terms — channel noise in cardiac tissue, synaptic noise in neural networks — the Jacobian becomes noisy and convergence fails. SolvSRK uses a proprietary noise-conditioning architecture that tolerates stochastic function evaluations natively. In dedicated medtech validation (450 runs), SolvSRK achieved 100% survival on all five medtech problems — cardiovascular Windkessel-3, 100-neuron FHN network, 11-compartment PBPK, bioreactor, and single FHN neuron — while BDF and Radau achieved 0% across all problems at sigma=0.001. CONFIRMED with Grade A evidence.